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Article

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

Developmental cell - 1 Feb 2005

Zhang Wensheng, Zhao Yun, Tong Chao, Wang Gelin, Wang Bing, Jia Jianhang, Jiang Jin

Abstract excerpt

Hedgehog (Hh) proteins control animal development by regulating the Gli/Ci family of transcription factors. In Drosophila, Hh counteracts phosphorylation by PKA, GSK3, and CKI to prevent Cubitus interruptus (Ci) processing through unknown mechanisms. Here, we show that these kinases physically interact with the kinesin-like protein Costal2 (Cos2) to control Ci processing and that Hh inhibits such interaction....

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Source

Identifiers

PMID: 15691767
DOI: 10.1016/j.devcel.2005.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.PMID 15691767Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.Semantic proximity Read ↗

Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.Semantic proximity Read ↗

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.Semantic proximity Read ↗

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila.Semantic proximity Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.Semantic proximity Read ↗

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.Semantic proximity Read ↗

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.Semantic proximity Read ↗

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