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Article

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.

Genes & development - 1 Aug 2007

Liu Yajuan, Cao Xuesong, Jiang Jin, Jia Jianhang

Abstract excerpt

The seven-transmembrane protein Smoothened (Smo) acts as a signal transducer in the Hedgehog (Hh) pathway that mediates many key developmental processes. In Drosophila, Hh-induced phosphorylation promotes Smo cell-surface accumulation and signaling activity; however, the mechanisms controlling Smo phosphorylation and cell-surface accumulation are still unknown. The intracellular signaling complex containing Fused...

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Identifiers

PMID: 17671093
DOI: 10.1101/gad.1557407
PMCID: PMC1935032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.PMID 17671093Read ↗

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Semantic proximity Read ↗

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.Semantic proximity Read ↗

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.Semantic proximity Read ↗

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesisSemantic proximity Read ↗

Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.Semantic proximity Read ↗

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.Semantic proximity Read ↗

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.Semantic proximity Read ↗

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Semantic proximity Read ↗

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.Semantic proximity Read ↗

An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.Semantic proximity Read ↗

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.Semantic proximity Read ↗

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