Article
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.
The Journal of biological chemistry - 19 Oct 2001
Fukumoto T, Watanabe-Fukunaga R, Fujisawa K, Nagata S, Fukunaga R
Abstract excerpt
The Drosophila segment polarity gene fused encodes a putative protein-serine/threonine kinase, and plays a critical role in the signal transduction for Hedgehog (Hh)-dependent gene expression. We show that the Drosophila Schneider 2 (S2) cell line has the potential to transduce the Hh-triggered intracellular signals, leading to the activation of target gene expression, when a transcription factor, Cubitus...
Topics
- Animals
- Blotting, Western
- Catalysis
- Cell Line
- DNA Mutational Analysis
- DNA, Complementary
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Drosophila
- Drosophila Proteins
- Genes, Reporter
- Hedgehog Proteins
- Insect Proteins