Article
An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.
Molecular and cellular biology - 1 Dec 2004
Ascano Manuel, Robbins David J
Abstract excerpt
The protein kinase Fused (Fu) is an integral member of the Hedgehog (Hh) signaling pathway. Although genetic studies demonstrate that Fu is required for the regulation of the Hh pathway, the mechanistic role that it plays remains largely unknown. Given our difficulty in developing an in vitro kinase assay for Fu, we reasoned that the catalytic activity of Fu might be highly regulated. Several mechanisms are known...
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