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Article

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Current biology : CB - 11 Aug 2009

Endoh-Yamagami Setsu, Evangelista Marie, Wilson Deanna, Wen Xiaohui, Theunissen Jan-Willem, Phamluong Khanhky, Davis Matti, Scales Suzie J, Solloway Mark J, de Sauvage Frederic J, Peterson Andrew S

Abstract excerpt

The Hedgehog (Hh) signaling pathway regulates development in animals ranging from flies to humans. Although its framework is conserved, differences in pathway components have been reported. A kinesin-like protein, Costal2 (Cos2), plays a central role in the Hh pathway in flies. Knockdown of a zebrafish homolog of Cos2, Kif7, results in ectopic Hh signaling, suggesting that Kif7 acts primarily as a negative...

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Identifiers

PMID: 19592253
DOI: 10.1016/j.cub.2009.06.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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