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Article

Detection of IDH1 and IDH2 mutations by fluorescence melting curve analysis as a diagnostic tool for brain biopsies.

The Journal of molecular diagnostics : JMD - 1 Jul 2010

Horbinski Craig, Kelly Lindsey, Nikiforov Yuri E, Durso Mary Beth, Nikiforova Marina N

Abstract excerpt

Novel mutations in the isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) genes have been identified in a large proportion of diffuse gliomas. Tumors with IDH1/2 mutations have distinctive clinical characteristics, including a less aggressive course. The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of...

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Source

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Identifiers

PMID: 20431032
DOI: 10.2353/jmoldx.2010.090228
PMCID: PMC2893633

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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