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Utility of real-time polymerase chain reaction for the assessment of CDKN2A homozygous deletion in adult-type IDH-mutant astrocytoma.

Brain tumor pathology - 1 Apr 2023

Shimizu Yuzaburo, Suzuki Mario, Akiyama Osamu, Ogino Ikuko, Matsushita Yuko, Satomi Kaishi, Yanagisawa Shunsuke, Ohno Makoto, Takahashi Masamichi, Miyakita Yasuji, Narita Yoshitaka, Ichimura Koichi, Kondo Akihide

Abstract excerpt

The World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5) introduced a newly defined astrocytoma, IDH-mutant grade 4, for adult diffuse glioma classification. One of the diagnostic criteria is the presence of a CDKN2A/B homozygous deletion (HD). Here, we report a robust and cost-effective quantitative polymerase chain reaction (qPCR)-based test for assessing...

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PMID: 36788155
DOI: 10.1007/s10014-023-00450-z

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