Article
Impact of PCR-based molecular analysis in daily diagnosis for the patient with gliomas.
Brain tumor pathology - 1 Jul 2018
Yokogami Kiyotaka, Yamasaki Koji, Matsumoto Fumitaka, Yamashita Shinji, Saito Kiyotaka, Tacheva Asya, Mizuguchi Asako, Watanabe Takashi, Ohta Hajime, Takeshima Hideo
Abstract excerpt
The WHO2016 CNS update requires a combined histological and molecular assessment. To assess the major aberrations such as co-deletion of complete chromosome arms 1p and 19q (Co-del), isocitrate dehydrogenase and histone H3 mutations, direct sequencing, multiplex ligation-dependent probe amplification and/or FISH are methods considered to be "golden standard" in the community. However, these methods are expensive...
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