Article
IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee.
Clinical neuropathology - 1 Jan 2000
Preusser M, Capper D, Hartmann C
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) gene mutations, primarily of the R132H type, occur in approximately 60 - 90% of diffuse and anaplastic gliomas and secondary glioblastomas. IDH mutations in gliomas are associated with several clinically relevant parameters including patient age, histopathological diagnosis, combined 1p/19q deletion, TP53 mutation, MGMT promoter hypermethylation and patient survival. Therefore,...
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