Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma.

Acta neuropathologica communications - 2 Jun 2014

Catteau Aurélie, Girardi Hélène, Monville Florence, Poggionovo Cécile, Carpentier Sabrina, Frayssinet Véronique, Voss Jesse, Jenkins Robert, Boisselier Blandine, Mokhtari Karima, Sanson Marc, Peyro-Saint-Paul Hélène, Giannini Caterina

Abstract excerpt

INTRODUCTION: Mutations in isocitrate dehydrogenase genes IDH1 or IDH2 are frequent in glioma, and IDH mutation status is a strong diagnostic and prognostic marker. Current IDH mutation screening is performed with an immunohistochemistry (IHC) assay specific for IDH1 R132H, the most common mutation. Sequencing is recommended as a second-step test for IHC-negative or -equivocal cases. We developed and validated a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Datasets as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Polymerase Chain Reaction

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24889502
DOI: 10.1186/2051-5960-2-58
PMCID: PMC4229941

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma.PMID 24889502Read ↗

Clinical Evaluation of IDH Mutation Status in Formalin-Fixed Paraffin-Embedded Tissue in Gliomas.Semantic proximity Read ↗

Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples.Semantic proximity Read ↗

Determining IDH-Mutational Status in Gliomas Using IDH1-R132H Antibody and Polymerase Chain ReactionSemantic proximity Read ↗

IDH mutation detection in formalin-fixed paraffin-embedded gliomas using multiplex PCR and single-base extension.Semantic proximity Read ↗

IDH1/2 mutation detection in gliomas.Semantic proximity Read ↗

Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues.Semantic proximity Read ↗

Expanding the spectrum of IDH1 mutations in gliomas.Semantic proximity Read ↗

Development of a Rapid and Sensitive IDH1/2 Mutation Detection Method for Glial Tumors and a Comparative Mutation Analysis of 236 Glial Tumor Samples.Semantic proximity Read ↗

Evaluation of the Idylla IDH1-2 Mutation Assay for the Detection of IDH Variants in Solid Tumors and Hematological Malignancies.Semantic proximity Read ↗

IDH1/2 gene hotspot mutations in central nervous system tumours: analysis of 922 Chinese patients.Semantic proximity Read ↗

Comparison of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, Immunohistochemistry, and DNA Sequencing for the Detection of IDH1 Mutations in Gliomas.Semantic proximity Read ↗

IDH mutation analysis in gliomas as a diagnostic and prognostic biomarker.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.