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Article

Clinical Evaluation of IDH Mutation Status in Formalin-Fixed Paraffin-Embedded Tissue in Gliomas.

Molecular diagnosis & therapy - 1 May 2023

Nelson Ernest J, Gubbiotti Maria A, Carlin Alicia M, Nasrallah MacLean P, Van Deerlin Vivianna M, Herlihy Sarah E

Abstract excerpt

BACKGROUND AND OBJECTIVE: Determination of isocitrate dehydrogenase (IDH) 1/2 mutational status is crucial for a glioma diagnosis. It is common for IDH mutational status to be determined via a two-step algorithm that utilizes immunohistochemistry studies for IDH1 R132H, the most frequent variant, followed by next-generation sequencing studies for immunohistochemistry-negative or immunohistochemistry-equivocal...

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Identifiers

PMID: 36690887
DOI: 10.1007/s40291-022-00638-7
PMCID: PMC9870658

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