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Article

Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues.

Journal of neuropathology and experimental neurology - 1 Dec 2009

Horbinski Craig, Kofler Julia, Kelly Lindsey M, Murdoch Geoffrey H, Nikiforova Marina N

Abstract excerpt

Mutations in isocitrate dehydrogenase enzyme isoforms 1 (IDH1) and 2 (IDH2) have been identified in many adult astrocytomas and oligodendrogliomas. These mutations are targeted to specific codons (e.g. R132 in IDH1 and R172 in IDH2), making assays to detect them in clinical specimens feasible. We describe a simple and accurate molecular assay for detection of IDH1/2 mutations on routine formalin-fixed...

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Source

Identifiers

PMID: 19915484
DOI: 10.1097/NEN.0b013e3181c391be

Genes

IDH1
IDH2

Provenance

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IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee.Semantic proximity Read ↗

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