Article
Clinical utility of plasma cell-free DNA (cfDNA) in diffuse gliomas for the detection of IDH1 R132H mutation.
Pathology, research and practice - 1 Nov 2024
Singh Swati, Bhardwaj Supriya, Dandapath Iman, Singh Jyotsna, Das Sumanta, Mohan Trishala, Bora Santanu Kumar, Kedia Shweta, Suri Ashish, Sharma Mehar Chand, Sarkar Chitra, Faruq Mohammed, Suri Vaishali
Abstract excerpt
Liquid biopsy for CNS tumors is in its nascent phase, hindered by the low levels of circulating tumor DNA (ctDNA). Overcoming this challenge requires highly sensitive molecular techniques. DD-PCR emerges as a standout technique due to its ability to identify rare mutations, copy number variations, and circulating nucleic acids, making it one of the best methods for identifying somatic mutations in cell-free DNA...
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