Article

The impact of the genetic background on gene deletion phenotypes in <i>Saccharomyces cerevisiae</i>

2018-12-04

Abstract excerpt

Loss-of-function (LoF) mutations associated with disease don’t manifest equally in different individuals, a phenomenon known as incomplete penetrance. The impact of the genetic background on incomplete penetrance remains poorly characterized. Here, we systematically assessed the changes in gene deletion phenotypes for 3,786 gene knockouts in four Saccharomyces cerevisiae strains and 38 conditions. We observed 16%...

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Literature Corpus work: b46cb864-18dc-50d1-927f-9a36673da917
DOI: 10.1101/487439

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