Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants.

Cells - 15 Feb 2023

Kim Sanghoon, Pajarillo Edward, Nyarko-Danquah Ivan, Aschner Michael, Lee Eunsook

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the aggregation of Lewy bodies in the basal ganglia, resulting in movement impairment referred to as parkinsonism. However, the etiology of PD is not well known, with genetic factors accounting only for 10-15% of all PD cases. The pathogenetic mechanism of PD is not completely understood, although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Dopamine
Share to Lewy Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Parkinson Disease

Share to Parkinsonian Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 36831289
DOI: 10.3390/cells12040622
PMCID: PMC9953822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants.PMID 36831289Read ↗

Metabolic alterations in Parkinson's disease astrocytes.Semantic proximity Read ↗

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?Semantic proximity Read ↗

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's DiseaseSemantic proximity Read ↗

Cellular and Molecular Mechanisms of Parkinson’s Disease: Neurotoxins, Causative Genes, and Inflammatory CytokinesSemantic proximity Read ↗

PINK1/Parkin-dependent mitophagy mediates astrocytic inflammatory responses to mitochondrial damageSemantic proximity Read ↗

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutationSemantic proximity Read ↗

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutationSemantic proximity Read ↗

The degeneration and replacement of dopamine cells in Parkinson’s disease: the role of agingSemantic proximity Read ↗

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6Semantic proximity Read ↗

Activated microglia contribute to paraquat neurotoxicity through neuroinflammation and regulation of phenotypic polarization of astrocytes.Semantic proximity Read ↗

Parkinson’s Disease-Related Genes and Lipid AlterationSemantic proximity Read ↗

PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic targetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.