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Article

Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy

16 Nov 2018

Abstract excerpt

Neuroinflammation and oligodendroglial cytoplasmic α-synuclein (α-syn) inclusions (GCIs) are important neuropathological characteristics of multiple system atrophy (MSA). GCIs are known to interfere with oligodendroglial maturation and consequently result in myelin loss. The neuroinflammatory phenotype in the context of MSA, however, remains poorly understood. Here, we demonstrate MSA-associated neuroinflammation...

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PMID: 30444295
DOI: 10.1111/bpa.12678

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