Article
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.
Blood - 8 Jul 2010
Liedtke Michaela, Ayton Paul M, Somervaille Tim C P, Smith Kevin S, Cleary Michael L
Abstract excerpt
MLL is a common target for chromosomal translocations associated with acute leukemia resulting in its fusion with a large variety of nuclear or cytoplasmic proteins that may activate its oncogenic properties by distinct but poorly understood mechanisms. The MLL-AF6 fusion gene represents the most common leukemogenic fusion of mixed lineage leukemia (MLL) to a cytoplasmic partner protein. Here, we identified a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.