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Article

MLL leukemia and future treatment strategies.

Archiv der Pharmazie - 1 Apr 2015

Marschalek Rolf

Abstract excerpt

Chromosomal rearrangements of the MLL gene are associated with high-risk infant, pediatric, adult, and therapy-induced acute leukemias. So far, about 80 different direct MLL fusions and about 120 reciprocal MLL fusions have been characterized at the molecular level. The common theme in these leukemia-associated genetic rearrangements is the genetic disruption of the MLL gene. This leads to MLL-X fusion proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

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Share to Myeloid-Lymphoid Leukemia Protein

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Source

Identifiers

PMID: 25740345
DOI: 10.1002/ardp.201400449

Genes

BRD4
CREBBP
MEN1
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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