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The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene

14 May 2002

Abstract excerpt

The LIM only protein Lmo2 plays an important role in hematopoiesis and leukemogenesis. Lmo2 acts as a bridging molecule between components of hematopoietic gene regulatory protein complexes. We used the yeast two-hybrid system to identify novel Lmo2 interacting proteins and found that the AF6 protein binds to Lmo2. AF6 is a recurrent fusion partner of MLL, the human homolog of Drosophila trithorax chromatin...

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PMID: 12067721
DOI: 10.1016/s0014-5793(02)02814-4

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