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Mixed lineage leukemia: roles in human malignancies and potential therapy

4 Mar 2010

Abstract excerpt

The increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia patients, makes it necessary to reflect on the cancer mechanism and to discuss potential therapeutic strategies. To date, 64 different translocations have been identified at the molecular level. With very few exceptions, most of the...

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PMID: 20236311
DOI: 10.1111/j.1742-4658.2010.07608.x

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