Article

RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation

2025-02-24

Abstract excerpt

Acute megakaryoblastic leukemia driven by the RBM15-MKL1 fusion protein (RM-AMKL) is the only known recurrent mutation involving the N6-methyladenosine (m6A) writer complex. Dysregulation of m6A modification affects RNA fate and is linked to oncogenesis. Inhibition of m6A deposition via inhibition of the METTL3 writer protein has anti-tumour activity, but the mechanism underlying its efficacy and cancer specificit...

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Literature Corpus work: 4691074a-241b-508f-b264-0438ec26bced
DOI: 10.1101/2025.02.19.638991

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