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The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment

22 Jun 2017

Abstract excerpt

Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion proteins, which could drive both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The lineage decision of MLL-fusion leukemia is influenced by the fusion partner and microenvironment. To investigate the interplay of fusion proteins and microenvironment in lineage choice, we transplanted human...

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PMID: 28637661
DOI: 10.1182/blood-2017-04-777185

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