Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

1 Jan 2013

Abstract excerpt

The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leukemic phenotypes even when expressed in the same cell type, but how this distinction is delineated on a molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Genomics and Chromatin Dynamics
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23352661
DOI: 10.1016/j.celrep.2012.12.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex InteractionPMID 23352661Read ↗

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.Semantic proximity Read ↗

Mixed lineage leukemia: roles in human malignancies and potential therapySemantic proximity Read ↗

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Semantic proximity Read ↗

Evolution of AF6-RAS association and its implications in mixed-lineage leukemiaSemantic proximity Read ↗

MLL leukemia and future treatment strategies.Semantic proximity Read ↗

Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.Semantic proximity Read ↗

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitmentSemantic proximity Read ↗

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological InterventionsSemantic proximity Read ↗

The ongoing conundrum of MLL-AF4 driven leukemogenesisSemantic proximity Read ↗

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Semantic proximity Read ↗

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.Semantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.