Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.

Leukemia - 1 Jun 2007

Kowarz E, Burmeister T, Lo Nigro L, Jansen M W J C, Delabesse E, Klingebiel T, Dingermann Theo, Meyer C, Marschalek R

Abstract excerpt

The human mixed lineage leukemia (MLL) gene is frequently involved in genetic rearrangements with more than 55 different translocation partner genes, all associated with acute leukemia. Reciprocal chromosomal translocations generate two MLL fusion alleles, where 5'- and 3'-portions of MLL are fus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromosomes, Human, Pair 11
Share to Chromosomes, Human, Pair 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Leukemia

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

Identifiers

PMID: 17410185
DOI: 10.1038/sj.leu.2404686

Genes

DSCAML1
ELF2
FXYD6
PBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17410185-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele.PMID 17410185Read ↗

Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.Semantic proximity Read ↗

The reciprocal world of MLL fusions: A personal viewSemantic proximity Read ↗

Mixed lineage leukemia: roles in human malignancies and potential therapySemantic proximity Read ↗

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex InteractionSemantic proximity Read ↗

The MLL recombinome of acute leukemias in 2013Semantic proximity Read ↗

MLL leukemia and future treatment strategies.Semantic proximity Read ↗

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4Semantic proximity Read ↗

Recurrent Fusion Genes in Leukemia: An Attractive Target for Diagnosis and TreatmentSemantic proximity Read ↗

Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.Semantic proximity Read ↗

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitmentSemantic proximity Read ↗

Identification of <i>MLL</i> partner genes in 27 patients with acute leukemia from a single cytogenetic laboratorySemantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.