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A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

2020-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Leukemias bearing fusions of the AF10/MLLT10 gene are associated with poor prognosis, and therapies targeting these fusion proteins are lacking. To understand mechanisms underlying AF10 fusion-mediated leukemogenesis, we generated inducible mouse models of AML driven by the most common AF10 fusion proteins, PICALM/CALM-AF10 and KMT2A/MLL-AF10, and performed comprehensive characterization of the...

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Identifiers and source

Literature Corpus work
c9828934-cd5d-5048-a38a-a3e192b1c8dc
DOI
10.1101/2020.08.31.273631
Open publication

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A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AMLDOI 10.1101/2020.08.31.273631
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