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Article

Protein arginine-methyltransferase-dependent oncogenesis.

Nature cell biology - 1 Oct 2007

Cheung Ngai, Chan Li Chong, Thompson Alex, Cleary Michael L, So Chi Wai Eric

Abstract excerpt

Enzymes that mediate reversible epigenetic modifications have not only been recognized as key in regulating gene expression and oncogenesis, but also provide potential targets for molecular therapy. Although the methylation of arginine 3 of histone 4 (H4R3) by protein arginine methyltransferase 1 (PRMT1) is a critical modification for active chromatin and prevention of heterochromatin spread, there has been no...

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Source

Identifiers

PMID: 17891136
DOI: 10.1038/ncb1642

Genes

PRMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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