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Article

End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism.

Organic & biomolecular chemistry - 21 Jun 2010

Ben Gaied Nouha, Richardson James A, Singleton Daniel G, Zhao Zhengyun, French David, Brown Tom

Abstract excerpt

HyBeacon probes have been used to characterise SNPs in the CYP2C9 and VKORC1 genes associated with variations in the efficiency of warfarin metabolism. PCR amplification of genomic DNA and probe target melting analysis provided a robust and reliable method to differentiate polymorphic sequences at these loci. Probes capped with 5'-trimethoxystilbene were found to exhibit larger fluorescence differences between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20393654
DOI: 10.1039/c001177k

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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