High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

doi:10.2217/pgs.13.66

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Article

High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Pharmacogenomics - 1 Jun 2013

Twist Greyson P, Gaedigk Roger, Leeder J Steven, Gaedigk Andrea

Abstract excerpt

High-resolution melt (HRM) analysis using 'release-on-demand' dyes, such as EvaGreen(®) has the potential to resolve complex genotypes in situations where genotype interpretation is complicated by the presence of pseudogenes or allelic variants in close proximity to the locus of interest. We explored the utility of HRM to genotype a SNP (785A>G, K262R, rs2279343) that is located within exon 5 of the CYP2B6 gene,...

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PMID: 23746185
DOI: 10.2217/pgs.13.66
PMCID: PMC3866959

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