Article
HyBeacon probes for rapid DNA sequence detection and allele discrimination.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
French David J, McDowell David G, Debenham Paul, Gale Nittaya, Brown Tom
Abstract excerpt
HyBeacon probes are single-stranded oligonucleotides with one or more internal base(s) labeled with a fluorescent dye. When a probe forms a duplex with its target sequence, the level of fluorescence emission increases considerably. HyBeacons have been developed as new tools for rapid sequence detection and discrimination and have been employed in a wide variety of applications including infectious diagnostics and...
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