Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SYBR Green-based real-time PCR assay for detection of VKORC1 and CYP2C9 polymorphisms that modulate warfarin dose requirement.

Clinical chemistry and laboratory medicine - 1 Jan 2009

Huang Sheng-Wen, Li Qiang, Zhu Sheng-Yuan, Li Liang, Xiong Fu, Jia Yan-Kai, Xu Xiang-Min

Abstract excerpt

BACKGROUND: Polymorphisms in VKORC1 (vitamin K epoxide reductase complex subunit 1) and CYP2C9 (cytochrome P450 2C9) genes are considered the major genetic factors modulating warfarin dose requirement. As a result, a rapid and economic method for genotyping patients for predicting warfarin dose could be useful in clinical applications. METHODS: In this study, we developed and validated a melting temperature...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzothiazoles
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diamines

Share to Organic Chemicals

Share to Quinolines

Share to Transition Temperature

Share to Vitamin K Epoxide Reductases

Share to Warfarin

Source

Identifiers

PMID: 19117406
DOI: 10.1515/CCLM.2009.008

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SYBR Green-based real-time PCR assay for detection of VKORC1 and CYP2C9 polymorphisms that modulate warfarin dose requirement.PMID 19117406Read ↗

Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.Semantic proximity Read ↗

Detection and identification of cytochrome P-450 2C9 alleles *1, *2, and *3 by high-resolution melting curve analysis of PCR amplicons.Semantic proximity Read ↗

High resolution melting method to detect single nucleotide polymorphism of VKORC1 and CYP2C9.Semantic proximity Read ↗

New allele-specific real-time PCR system for warfarin dose genotyping equipped with an automatic interpretative function that allows rapid, accurate, and user-friendly reporting in clinical laboratories.Semantic proximity Read ↗

[Development of the high resolution melting method for genotyping CYP2C9*3 (1075A/C, rs1057910) and VKORC1 (-1639A/G, rs9923231)].Semantic proximity Read ↗

Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.Semantic proximity Read ↗

Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing.Semantic proximity Read ↗

Rapid screening for targeted genetic variants via high-resolution melting curve analysis.Semantic proximity Read ↗

Pharmacogenetic distribution of warfarin and its clinical significance in Korean patients during initial anticoagulation therapy.Semantic proximity Read ↗

Performance of commercial platforms for rapid genotyping of polymorphisms affecting warfarin dose.Semantic proximity Read ↗

Cross-Validation of High-Resolution Melting Analysis-Based Genotyping Platform.Semantic proximity Read ↗

Comparison of performance of three commercial platforms for warfarin sensitivity genotyping.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.