Ultra-rapid DNA analysis using HyBeacon probes and direct PCR amplification from saliva.

doi:10.1006/mcpr.2002.0425

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Article

Ultra-rapid DNA analysis using HyBeacon probes and direct PCR amplification from saliva.

Molecular and cellular probes - 1 Oct 2002

French D J, Archard C L, Andersen M T, McDowell D G

Abstract excerpt

We describe a novel probe technology, termed HyBeacons, which provides a new homogeneous method for fluorescence-based sequence detection and allele discrimination. Employing a single nucleotide polymorphism located in the N-acetyltransferase 2 gene as a model system, we demonstrate the utility of HyBeacon probes for rapid and reliable sequence analysis. We also demonstrate that homozygous and heterozygous...

Topics

Arylamine N-Acetyltransferase
DNA
DNA Mutational Analysis
DNA Probes
Fluorescent Dyes
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Saliva
Temperature
Time Factors

Source

Open in PubMed

Identifiers

PMID: 12477435
DOI: 10.1006/mcpr.2002.0425

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