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Article

Detection and identification of cytochrome P-450 2C9 alleles 1, 2, and *3 by high-resolution melting curve analysis of PCR amplicons.

American journal of clinical pathology - 1 Apr 2006

Hill Charles E, Duncan Alexander, Wirth Diane, Nolte Frederick S

Abstract excerpt

High-resolution melting curve analysis using a fluorescent DNA binding dye can detect sequence variations in a closed-tube system without labeled primers or probes. We developed and verified a melting analysis assay for common single nucleotide polymorphisms of cytochrome P-450 (CYP) 2C9 that affect warfarin metabolism. We used this method to genotype 84 patients receiving warfarin. For wild-type, *1/*1, 50%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16627267
DOI: 10.1309/76QP-HQ89-2F17-QKNC

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