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Article

Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing.

Journal of thrombosis and thrombolysis - 1 Aug 2008

Carlquist John F, McKinney Jason T, Nicholas Zachary P, Clark Jessica L, Kahn Samera F, Horne Benjamin D, Muhlestein Joseph B, May Heidi T, Anderson Jeffrey L

Abstract excerpt

Warfarin anticoagulation therapy is complicated by its narrow therapeutic index and by wide inter-individual differences in dosing requirements arising, in part, from genetic factors. The present report describes the development, validation and feasibility testing of a rapid genotyping assay that concurrently detects the CYP2C9*2 and *3 variants along with the VKORC1 C1173T polymorphism. The study employed...

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Source

Identifiers

PMID: 17661181
DOI: 10.1007/s11239-007-0077-x

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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