Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon® probes.

Clinica chimica acta; international journal of clinical chemistry - 20 Nov 2011

Howard Rebecca, Leathart Julian B S, French David J, Krishan Elaina, Kohnke Hugo, Wadelius Mia, van Schie Rianne, Verhoef Talitha, Maitland-van der Zee Anke-Hilse, Daly Ann K, Barallon Rita

Abstract excerpt

BACKGROUND: Coumarin anticoagulants such as warfarin are used to treat and prevent thromboembolic events in patients. The required dosage is difficult to predict and the risk of over or under anticoagulation are dependent on several environmental and clinical factors, such as concurrent medication, diet, age and genotype for polymorphisms in two genes CYP2C9 and VKORC1. METHODS: A novel fluorescent PCR genotyping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Mixed Function Oxygenases

Share to Point-of-Care Systems

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Vitamin K Epoxide Reductases

Source

Identifiers

PMID: 21827742
DOI: 10.1016/j.cca.2011.07.013

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon® probes.PMID 21827742Read ↗

Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping.Semantic proximity Read ↗

A multiplex assay for detecting genetic variations in CYP2C9, VKORC1, and GGCX involved in warfarin metabolism.Semantic proximity Read ↗

Comparison of performance of three commercial platforms for warfarin sensitivity genotyping.Semantic proximity Read ↗

Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.Semantic proximity Read ↗

Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.Semantic proximity Read ↗

The prevalence of VKORC1 1639 G>A and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population.Semantic proximity Read ↗

Characterization of Reference Materials with an Association for Molecular Pathology Pharmacogenetics Working Group Tier 2 Status: CYP2C9, CYP2C19, VKORC1, CYP2C Cluster Variant, and GGCX: A GeT-RM Collaborative Project.Semantic proximity Read ↗

Determination of genotypes using a fully automated molecular detection system.Semantic proximity Read ↗

Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin.Semantic proximity Read ↗

Rationalized DNA sequencing-based protocol for genotyping patients receiving coumarin therapy.Semantic proximity Read ↗

HyBeacon probes for rapid DNA sequence detection and allele discrimination.Semantic proximity Read ↗

Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.