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Article

Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants.

Cellular and molecular life sciences : CMLS - 1 Sept 2010

Ambrosio Manuela, Fanelli Francesca, Brocchetti Silvia, Raimondi Francesco, Mauri Mario, Rovati G Enrico, Capra Valérie

Abstract excerpt

In class A GPCRs the E/DRY motif is critical for receptor activation and function. According to experimental and computational data, R3.50 forms a double salt bridge with the adjacent E/D3.49 and E/D6.30 in helix 6, constraining the receptor in an inactive state. The disruption of this network of interactions facilitates conformational transitions that generate a signal or constitutive activity. Here we...

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Identifiers

PMID: 20383734
DOI: 10.1007/s00018-010-0368-9
PMCID: PMC11115618

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Source receipt: pubmed, retrieved 7 Sept 2026.

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