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Article

Dynamic behavior of the active and inactive states of the adenosine A(2A) receptor.

The journal of physical chemistry. B - 27 Mar 2014

Lee Sangbae, Bhattacharya Supriyo, Grisshammer Reinhard, Tate Christopher, Vaidehi Nagarajan

Abstract excerpt

The adenosine A2A receptor (A2AR) belongs to the superfamily of membrane proteins called the G-protein-coupled receptors (GPCRs) that form one of the largest superfamilies of drug targets. Deriving thermostable mutants has been one of the strategies used for crystallization of A2AR in both the agonist and antagonist bound conformational states. The crystal structures do not reveal differences in the activation...

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Share to Adenosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

Share to Receptor, Adenosine A2A

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 24579769
DOI: 10.1021/jp411618h
PMCID: PMC3983344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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