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Article

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms.

BMC biology - 5 Feb 2026

Chen Yue, Saarinen Marcus, Naraine Akshay, Carlsson Jens, Svenningsson Per, Delemotte Lucie

Abstract excerpt

BACKGROUND: G protein-coupled receptors (GPCRs) can signal in the absence of agonists through constitutive activity. This activity can be enhanced by mutations, resulting in receptors known as constitutively active mutants (CAMs). Such receptors are implicated in various physiological and pathophysiological conditions, and also offer significant therapeutic potential. However, the molecular basis of their...

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PMID: 41639670
DOI: 10.1186/s12915-026-02542-6
PMCID: PMC12930580

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