Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

Molecular pharmacology - 1 Apr 2007

Rovati G Enrico, Capra Valérie, Neubig Richard R

Abstract excerpt

Despite extensive study of heptahelical G protein-coupled receptors (GPCRs), the precise mechanism of G protein activation is unknown. The role of one highly conserved stretch of residues, the amino acids glutamic acid/aspartic acid-arginine-tyrosine (i.e., the E/DRY motif), has received considerable attention with respect to regulating GPCR conformational states. In the consensus view, glutamic acid/aspartic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Conserved Sequence
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Conformation

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 17192495
DOI: 10.1124/mol.106.029470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.PMID 17192495Read ↗

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.Semantic proximity Read ↗

Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.Semantic proximity Read ↗

Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.Semantic proximity Read ↗

Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Semantic proximity Read ↗

The G-protein coupled receptor family: actors with many faces.Semantic proximity Read ↗

Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants.Semantic proximity Read ↗

Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor ActivitySemantic proximity Read ↗

Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor.Semantic proximity Read ↗

Role of the conserved DRY motif on G protein activation of rat angiotensin II receptor type 1A.Semantic proximity Read ↗

Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.Semantic proximity Read ↗

G-protein activation of the dark-state conformation of the visual G protein-coupled receptor rhodopsin by releasing critical structural constraints.Semantic proximity Read ↗

<i>In vitro</i> profiling of orphan G protein coupled receptor (GPCR) constitutive activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.