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Article

Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity

9 Oct 2006

Abstract excerpt

G protein-coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules. The notion that GPCRs also signal without an external chemical trigger, i.e., in a constitutive or spontaneous manner, resulted in a paradigm shift in the field of GPCR pharmacology. The discovery of constitutive GPCR activity and the fact that GPCR binding and signaling can be strongly affected by a...

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PMID: 17029567
DOI: 10.1146/annurev.pharmtox.47.120505.105126

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