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Article

Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation.

Journal of neurochemistry - 1 Aug 2012

Pydi Sai Prasad, Bhullar Rajinder Pal, Chelikani Prashen

Abstract excerpt

The human bitter taste receptors (T2Rs) belong to the G-protein coupled receptor (GPCR) superfamily. T2Rs share little homology with the large subfamily of Class A G-protein coupled receptors, and their mechanisms of activation are poorly understood. Guided by biochemical and molecular approaches, we identified two conserved amino acids Gly28¹·⁴⁶ and Ser285⁷·⁴⁷ present on transmembrane (TM) helices, TM1 and TM7,...

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Identifiers

PMID: 22639948
DOI: 10.1111/j.1471-4159.2012.07808.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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