Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation.

doi:10.1111/j.1471-4159.2012.07808.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation.

Journal of neurochemistry - 1 Aug 2012

Pydi Sai Prasad, Bhullar Rajinder Pal, Chelikani Prashen

Abstract excerpt

The human bitter taste receptors (T2Rs) belong to the G-protein coupled receptor (GPCR) superfamily. T2Rs share little homology with the large subfamily of Class A G-protein coupled receptors, and their mechanisms of activation are poorly understood. Guided by biochemical and molecular approaches, we identified two conserved amino acids Gly28¹·⁴⁶ and Ser285⁷·⁴⁷ present on transmembrane (TM) helices, TM1 and TM7,...

Topics

Alanine
Amino Acids
Calcium
Cell Line, Transformed
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Humans
Hydrogen Bonding
Models, Molecular
Mutation
Quaternary Ammonium Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quinine

Receptors, G-Protein-Coupled

Serine

Signal Transduction

Stimulation, Chemical

Taste

Transfection

Source

Open in PubMed

Identifiers

PMID: 22639948
DOI: 10.1111/j.1471-4159.2012.07808.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation.PMID 22639948Read ↗

Constitutive activity of bitter taste receptors (T2Rs).Semantic proximity Read ↗

Functional molecular switches of mammalian G protein-coupled bitter-taste receptors.Semantic proximity Read ↗

Functional Molecular Switches of Mammalian G Protein-Coupled Bitter-Taste ReceptorsSemantic proximity Read ↗

The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling.Semantic proximity Read ↗

Mutant G-protein-coupled receptors as a cause of human diseases.Semantic proximity Read ↗

Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.Semantic proximity Read ↗

Characterization of constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.Semantic proximity Read ↗

Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Semantic proximity Read ↗

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.Semantic proximity Read ↗

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.Semantic proximity Read ↗

G protein-coupled receptors: abnormalities in signal transmission, disease states and pharmacotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.