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Article

G protein-coupled receptors: a count of 1001 conformations.

Fundamental & clinical pharmacology - 1 Feb 2005

Vauquelin G, Van Liefde I

Abstract excerpt

G protein-coupled receptors (GPCRs) were initially regarded to adopt an inactive and an active conformation and to activate a single type of G protein. Studies with recombinant cell systems have led to a more complex picture. First, GPCRs can activate distinct G protein species. Second, GPCR multistate models have been invoked to explain their complex behaviour in the presence of agonists, antagonists and other...

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Identifiers

PMID: 15660959
DOI: 10.1111/j.1472-8206.2005.00319.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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