Article
Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
Neurobiology of aging - 1 Mar 2011
Ricci Claudia, Battistini Stefania, Cozzi Lorena, Benigni Michele, Origone Paola, Verriello Lorenzo, Lunetta Christian, Cereda Cristina, Milani Pamela, Greco Giuseppe, Patrosso Maria Cristina, Causarano Renzo, Caponnetto Claudia, Giannini Fabio, Corbo Massimo, Penco Silvana
Abstract excerpt
Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON...
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