Article
A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
Neurology - 7 Jul 2009
Wills A-M, Cronin S, Slowik A, Kasperaviciute D, Van Es M A, Morahan J M, Valdmanis P N, Meininger V, Melki J, Shaw C E, Rouleau G A, Fisher E M C, Shaw P J, Morrison K E, Pamphlett R, Van den Berg L H, Figlewicz D A, Andersen P M, Al-Chalabi A, Hardiman O, Purcell S, Landers J E, Brown R H
Abstract excerpt
BACKGROUND: Six candidate gene studies report a genetic association of DNA variants within the paraoxonase locus with sporadic amyotrophic lateral sclerosis (ALS). However, several other large studies, including five genome-wide association studies, have not duplicated this finding. METHODS: We conducted a meta-analysis of 10 published studies and one unpublished study of the paraoxonase locus, encompassing 4,037...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.