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Article

Paraoxonase gene polymorphisms and sporadic ALS.

Neurology - 12 Sept 2006

Slowik A, Tomik B, Wolkow P P, Partyka D, Turaj W, Malecki M T, Pera J, Dziedzic T, Szczudlik A, Figlewicz D A

Abstract excerpt

BACKGROUND: The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and PON3, located adjacent to each other on chromosome 7. PON catalytic activity may be influenced by frequent amino acid variants. Chronic exposure to certain chemicals or to environmental factors causing enhanced lipid peroxidation metabolized by paraoxonases may be a risk factor for sporadic ALS (sALS). OBJECTIVE: The...

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Source

Identifiers

PMID: 16822965
DOI: 10.1212/01.wnl.0000219565.32247.11

Genes

PON1
PON2
PON3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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