A common haplotype within the PON1 promoter region is associated with sporadic ALS.

doi:10.1080/17482960802233177

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Article

A common haplotype within the PON1 promoter region is associated with sporadic ALS.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Oct 2008

Landers John E, Shi Lijia, Cho Ting-Jan, Glass Jonathan D, Shaw Christopher E, Leigh P Nigel, Diekstra Frank, Polak Meraida, Rodriguez-Leyva Ildefonso, Niemann Stephan, Traynor Bryan J, McKenna-Yasek Diane, Sapp Peter C, Al-Chalabi Ammar, Wills Anne-Marie A, Brown Robert H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disorder of upper and lower motor neurons. Genetic variants in the paraoxonase gene cluster have been associated with susceptibility to sporadic ALS. Because these studies have yielded conflicting results, we have further investigated this association in a larger data set. Twenty SNPs spanning the paraoxonase gene cluster were genotyped on a...

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Identifiers

PMID: 18618303
DOI: 10.1080/17482960802233177
PMCID: PMC2739087

Genes

PON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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