Article
Rare and common paraoxonase gene variants in amyotrophic lateral sclerosis patients.
Neurobiology of aging - 1 Aug 2012
van Blitterswijk Marka, Blokhuis Anna, van Es Michael A, van Vught Paul W J, Rowicka Paulina A, Schelhaas Helenius J, van der Kooi Anneke J, de Visser Marianne, Veldink Jan H, van den Berg Leonard H
Abstract excerpt
Polymorphisms in the paraoxonase family (PON) have been reported in patients with amyotrophic lateral sclerosis (ALS), but a recent meta-analysis did not show a clear association. Recently, PON mutations have also been identified in ALS patients. In this study, we assessed the frequency of PON variants in 1118 sporadic ALS patients, 93 familial ALS patients, and 1240 control subjects of Dutch descent. We...
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