Article
No association of GSTP1 rs1695 polymorphism with amyotrophic lateral sclerosis: A case-control study in the Brazilian population.
PloS one - 1 Jan 2021
Barros Jéssica Barletto de Sousa, Santos Kamilla de Faria, Azevedo Rômulo Morais, de Oliveira Rayana Pereira Dantas, Leobas Ana Carolina Dourado, Bento Dhiogo da Cruz Pereira, Santos Rodrigo da Silva, Reis Angela Adamski da Silva
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disease that affects motor neurons and promotes progressive muscle atrophy. It has a multifactorial etiology, where environmental conditions playing a remarkable role through the increase of oxidative stress. Genetic polymorphisms in cell detoxification genes, such as Glutathione S-Transferase Pi 1 (GSTP1) can contribute to excessive oxidative...
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