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Article

Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis.

Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2007

Cronin Simon, Greenway Matthew J, Prehn Jochen H M, Hardiman Orla

Abstract excerpt

BACKGROUND: The paraoxonases, PON1-3, play a major protective role both against environmental toxins and as part of the antioxidant defence system. Recently, non-synonymous coding single nucleotide polymorphisms (SNPs), known to lower serum PON activity, have been associated with sporadic ALS (SALS) in a Polish population. A separate trio based study described a detrimental allele at the PON3 intronic variant...

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Source

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Identifiers

PMID: 17702780
DOI: 10.1136/jnnp.2006.112581
PMCID: PMC2117866

Genes

PON1
PON3
PON2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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