Article
Association analysis of the paraoxonase-1 gene with Alzheimer's disease.
Neuroscience letters - 20 Nov 2006
Cellini Elena, Tedde Andrea, Bagnoli Silvia, Nacmias Benedetta, Piacentini Silvia, Bessi Valentina, Bracco Laura, Sorbi Sandro
Abstract excerpt
Genetic variants in the paraoxonase (PON) gene cluster, particularly a single C/T promoter polymorphism (rs 705381) in the PON-1 gene, have recently been associated with Alzheimer's disease (AD). The T allele, in particular, presents an increased risk for the development of AD. Here, we investigate the potential role of this polymorphism in an Italian case-control population consisting of 306 sporadic AD patients...
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