Article
Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.
Obesity (Silver Spring, Md.) - 1 Dec 2010
Liu Yong-Jun, Guo Yan-Fang, Zhang Li-Shu, Pei Yu-Fang, Yu Na, Yu Ping, Papasian Christopher J, Deng Hong-Wen
Abstract excerpt
Recent genome-wide association (GWA) studies have identified a number of novel genes/variants predisposing to obesity. However, most GWA studies have focused on individual single-nucleotide polymorphism (SNPs)/genes with a strong statistical association with a phenotypic trait without considering potential biological interplay of the tested genes. In this study, we performed biological pathway-based GWA analysis...
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